Genomes of probiotic bacteria encode an unsually large number of enzymes and proteins related to carbohydrate metabolism. Some carbohydrates are prebiotic; stimulating growth of probiotic bacteria, with corresponding beneficial effects on gut microbiota and diseases like cancer and inflammation. Insight into molecular interactions between proteins from probiotic bacteria and prebiotic carbohydrates will make it possible to identify determinants for recognition and to uncover the mechanisms behind the beneficial effects. Our strategy is focused on discovery of the carbohydrate active enzymes responsible for these prebiotics, through genome-mining and differential proteomics integrated with gene expression analysis. The data will enable selection of synbiotics to test on human gut microbiota in intervention studies and colon simulation analysis. The aim is to develop new prebiotics and synbiotics that will expand consumers’ food choice and counteract lifestyle-related diseases.

For detailed project information, please contact Professor Birte Svensson (), Associate Professor Susanne Jacobsen() or Associate Professor Maher Abou Hachem ().